Alcohol Metabolism How does the human body break down alcohol? ADH + ALDH Enzymes Alcohol metabolism is carried out by alcohol dehydrogenase enzymes (ADH) and aldehyde dehydrogenase enzymes (ALDH) in the body1.  These enzymes require specific cofactors and coenzymes to perform their job. Cofactors & Coenzymes Zinc and nicotinamide adenine dinucleotide (NAD) are the essential … Continue reading SCIENCE OF ALCOHOL METABOLISM