Recoverthol is a new liquid formulation for the symptomatic relief of hangover. It has been specifically formulated to be added to an alcoholic drink (without affecting the taste of your drink). This targeted delivery method allows Alcohol Dehydrogenase cofactors (which are fuel for alcohol metabolising enzymes) to reach the enzymes at the same time as alcohol. This is why you add it to your first alcoholic drink. This way, the alcohol dehydrogenase enzyme can continue to work efficiently.
Higher absorption rate is achieved via removing the dissolution step involved in the absorption of tablets and capsules. As a liquid formulation, Recoverthol does not require this dissolution process to work, and hence, may be absorbed faster than tablets.
How is alcohol metabolised?
Alcohol is metabolised by two enzymes: Alcohol dehydrogenase (ADH) and Aldehyde dehydrogenase (ALDH). Alcohol undergoes a two-step process in its enzymatic metabolism pathway1 . Firstly, ethanol is metabolised by ADH to produce acetaldehyde, which is a highly toxic molecule—and known to cause the symptoms of hangover2. Acetaldehyde is then metabolised via ALDH to acetate, which is then further broken down into carbon dioxide and water which is eliminated by the body.
Figure 1 outlines the enzymatic pathway for alcohol metabolism.
Enzymes require other molecules to perform their reaction. ADH and ALDH enzymes use zinc as a cofactor that holds the alcohol in its place, and Nicotinamide adenine dinucleotide (NAD) as the coenzyme which performs the chemical reaction on alcohol3. The levels of these cofactors and coenzymes deplete during alcohol consumption4.
Recoverthol is a pre-drink supplement
Recoverthol will give you an extra dose of these essential cofactors to firstly replenish what you have used up, and also to provide you with an extra dose of these cofactors WHILST drinking. This may reduce the build up of acetaldehyde and reduce the presentation and/or severity of hangover symptoms7,8.
Cofactors and coenzymes
So what are these cofactors and coenzymes? You may be surprised to know that your body contains these ingredients naturally (i.e. the ingredients of Recoverthol)- but only enough to process about 1-2 standard drinks (depending on you weight, gender and other factors). Recoverthol simply helps to replenish the cofactors that your body uses up when you drink, supporting the ongoing metabolism of alcohol.
Recoverthol is not a hangover cure or a hangover prevention product. Recoverthol is a supplement to provide additional cofactors and co-enzyme precursors that are used up when you drink alcohol.
Recoverthol is not a blend of amino acids or exotic herbs to allow you to drink as much as you want!.
Recoverthol has been scientifically formulated based on medical knowledge of alcohol metabolism to support alcohol dehydrogenase enzyme to do its job.
Ask your pharmacist how Recoverthol can help you manage your hangover symptoms.
Any amount of alcohol can affect your health. Alcohol has short-term and long-term side effects. There is no way to avoid or prevent these side effects, other than to avoid alcohol altogether. If you do choose to drink alcohol, however, there are safety measures you can take, such as following the recommended safe intake guidelines, counting your drinks, and taking a dietary supplement to help you replenish the nutrients lost when drinking alcohol. Drink Responsibly to be on your A-game, because tomorrow matters.
“Always read the label”, “use only as directed” and “if symptoms persist see your doctor/healthcare professional”
*Individual results may vary.
- Swift R, Davidson D. Alcohol hangover. mechanisms and mediators. Alcohol Health & Research World. 1998; 22(1): 54-60.
- US Department of Health and Human Services. Alcohol Alert. July 2007. Accessed 10/12/2018. Available at: https://pubs.niaaa.nih.gov/publications/aa72/aa72.htm
- Hasim OH, Adnan NA. Coenzyme, cofactor and prosthetic group ambiguous biochemical jargon. Biochemical Education, 1994: 22(2); 93-
- Liver and Alcohol breakdown. myDr. Reviewed 9/12/2015. Accessed 10/12/2018. Available at: https://www.mydr.com.au/gastrointestinalhealth/liver-and-alcohol-breakdown
- Umulis DM, Gurmen NM, Singh P, Fogler HS. A physiologically based model for ethanol and acetaldehyde metabolism in human beings. Alcohol. 2005; 35(1): 3-12.
- Wang F, Li Y, Zhang YJ, Zhou Y, Li S, Li HB. Natural products for the prevention and treatment of hangover and alcohol use disorder. Molecules. 2016; 21(1): 64.
- Swift R. Drug therapy for alcohol dependence. New Engl J Med. 1999 May 13;340(19):1482-90.
- Vopli E, Lucidi P, Criciani G, Monacchia F, Reboldi G, Brunetti P, Bolli GB, De Feo P. Nicotinamide counteracts alcohol-induced impairment of hepatic protein metabolism in humans. J Nutr. 1997; 127(11): 2199-204.