SCIENCE OF ALCOHOL METABOLISM

Alcohol metabolism: 

Alcohol is metabolized (broken down) by the body at a rate of 0.016% per hour. It doesn’t matter if you are 6’4” or 4’6,” or if you drink red wine or moonshine. Once your blood alcohol concentration (BAC) reaches a certain level, no matter how it got to that level, your body needs time to break the alcohol down and remove it from your system. The bulk of ingested alcohol is metabolised in the liver and initiated by an enzyme called alcohol dehydrogenase (ADH). This enzyme is responsible for the alcohol metabolism in the body. In order to work, this enzyme requires helper compounds, namely Alcohol Dehydrogenase (ADH) cofactors. This enzyme, in our liver and stomach, has been reported to effectively detoxify about one drink each hour. When people drink more than one alcoholic drink per hour, alcohol cannot be metabolized efficiently. As a result, toxic by products builds up causing the symptoms of hangover such as headache, fatigue, nausea, dehydration, and sensitivity to light etc. By providing an additional supply of alcohol dehydrogenase cofactors to the liver when drinking exceeds one drink per hour, the metabolism of alcohol can carry on and may reduce the build up of toxic by-products and the subsequent development of hangover symptoms. The more efficient metabolism of alcohol will also serve to protect the liver from the damaging effects of alcohol metabolism. Some people have genetically lower levels of ADH enzymes, including women and some ethnic groups. This causes a faster build up of toxic by-products when drinking alcohol, and possibly, more severe hangover symptoms. Unfortunately, the liver’s stores of ADH Cofactors quickly run out when larger amounts of alcohol enter the system. This causes a toxic byproduct called acetaldehyde to build up in the body. Although body weight is a factor, part of the reason women should not keep up with men drink-for-drink, is because women have less acetaldehyde dehydrogenase, making their hangovers worse. The female body typically takes longer to break down alcohol than the male body, as a result of having lower levels of naturally occurring alcohol metabolising enzymes.

Recoverthol promotes the efficient metabolism of alcohol.

The Recoverthol formulation contains ADH cofactors and other proprietary ingredients. From what we know about alcohol metabolism, increasing the amount of ADH cofactors within the body will logically enhance the break down of alcohol and may reduce the build up of toxic by products and the development of hangover symptoms. It has also been reported in scientific journals that administering ADH cofactors to humans drinking high volumes of alcohol may reduce the build up of acetaldehyde, the toxic by product that causes the nasty symptoms of hangover.

chemistry of alcohol metabolismWhat Causes a Hangover?

There are 7 major biochemical reactions to alcohol metabolism.

Alcohol, and too much of it, triggers a cascade of reactions in your body that contribute to the symptoms known as a hangover. These include:

  1. Increased Urination: Alcohol is a diuretic. For every 200 ml of alcohol consumed, you will produce 320ml of urine. Alcohol inhibits the secretion of vasopressin. When this enzyme is suppressed, water is sent right to your bladder (along with electrolytes) to be excreted, causing you to urinate more often.
  1. Dehydration: Increased urination can lead you to become quickly dehydrated, and as your body draws water from your brain to function, it may leave you feeling fatigued or dizzy.
  1. Acetaldehyde build-up: When alcohol reaches your liver, an enzyme called alcohol dehydrogenase breaks it down into acetaldehyde. Acetaldehyde is far more toxic than alcohol (by up to 30-fold). So your body again attempts to break it down with the enzyme acetaldehyde dehydrogenase and glutathione, a powerful antioxidant that is crucial for liver detoxification (glutathione contains high levels of cysteine, which is why taking this in supplement form may help avoid hangover symptoms. Together, this powerful detox duo can break down the acetaldehyde into harmless acetate (which is similar to vinegar). However, when you drink too much alcohol, your stores of glutathione become depleted, which allows acetaldehyde to build up in your body, causing the toxic hangover effect. It should be noted that women have less acetaldehyde dehydrogenase and glutathione than men, which is why women may have a more severe reaction to drinking the same amount of alcohol as a man of similar weight.
  1. Congeners: Congeners are ingredients produced as byproducts of fermentation and distillation. They include acetone, acetaldehyde, tannins, and some flavorants in different alcoholic beverages. Congeners are thought to make the effects of a hangover worse and are found in higher amounts in darker liquors (such as brandy, whiskey, and red wine) than clear liquors like vodka or gin.
  1. Glutamine rebound: Alcohol inhibits glutamine, a natural stimulant in your body. This is partly why alcohol has a depressive effect that may make you fall asleep easily… at first. After you’ve stopped drinking, your body will work overtime increasing glutamine levels, which is why you’ll ultimately wake up more often and have a more restless night’s sleep after you drink. This glutamine rebound may contribute to the fatigue, tremors, anxiety, restlessness, and even increased blood pressure that are often felt during a hangover.
  1. Disruptions to your stomach lining, blood vessels, and blood sugar: Alcohol is irritating to your stomach lining and leads to an increased production of stomach acid. This can cause nausea, vomiting, and stomach pain. Alcohol can also lead to dips in your blood sugar level, which can lead to shakiness, mood swings, fatigue, and seizures. Also, alcohol may cause your blood vessels to expand, which may trigger headaches.
  1. Inflammatory response: Finally, alcohol also provokes an inflammatory response in your body in which your immune system may trigger agents that provoke hangover symptoms including memory problems, decreased appetite, and trouble concentrating.

How does Recoverthol works?

When you drink alcohol, your liver gets to work using Alcohol dehydrogenase enzyme and its cofactors (i.e. Recoverthol), to slowly filter out the alcohol in your system. An extra dose of these cofactors WHILST you are drinking, is essential to replenish what you have used up in order to avoid hangover symptoms. WHO recommends we should only drink 2 standard drinks per night, because that is what our liver can handle. But lets face it, sometimes we drink more that what we should. So when you indulge you need to have a Recoverthol. Without it, you are going to stress your liver. Recoverthol is not a blend of amino acids or exotic herbs. Recoverthol is the only product that is scientifically formulated and tested, based on medical knowledge of alcohol metabolism.

When we exercise, we need extra water to rehydrate. The same principle applies when drinking alcohol. You need to replace the ADH cofactors that you have used up. So just like you have some water when you exercise, you need Recoverthol when you drink alcohol.